Figure S6.

Marker Chromosomes Created by Chromothripsis, Related to Figure 6

(A) Multicolor FISH for the three heavily amplified probes in SCLC-21H (shown in Figure 6B) together with whole chromosome paint for chromosome 8 (purple). The normal chromosome 8 has the three probes in the correct orientation, whereas the probes do not hybridize to the two derivative chromosomes.

(B) A rearrangement screen from a pancreatic cancer, PD3646a, previously published (Campbell et al., 2010), shows 41 rearrangements involving chromosomes 1, 4, 10 and 14. Copy number profiles for the relevant chromosomes are in the outer ring with somatically acquired genomic rearrangements shown as arcs in the centre.

(C) Spectral karyotype for PD3646a shows a striped marker chromosome, with at least 6 cytogenetically visible segments arising from multiple chromosomes. The bright yellow signal corresponds to paint from chromosome 22, but the other stripes are characteristic of signals from chromosomes 1, 4, 10 and 14.