Skip to main content
. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Pharmacol Ther. 2010 Oct 21;129(3):241–259. doi: 10.1016/j.pharmthera.2010.09.010

Figure 7. Functional validation in vitro and in vivo of the receptor transcripts identified in single warm sensitive neuron cDNA libraries: Hypothermic and hyperthermic effects can be exerted through receptors of warm sensitive neurons identified by single cell transcriptomics and validated by use of the recptor agonist injected into the POA and tested on the firing rate of WSN in POA slice.

Figure 7

Bombesin acting at BSR3 receptor activates firing of the warm sensitive neurons and causes hypothermia upon POA injection, while Prolactin inhibits firing of warm sensitive neurons and upon injection into the POA causes hyperthermia, respectively.