Table 4. Functional validation studies on receptor cDNAs.
Known and orphan GPCRs cDNAs in the transcriptome of warm sensitive neurons that were studied to validate expression of functional receptors in vitro and in vivo
| Receptor | Ligand | Validation |
|---|---|---|
| CRF2 | Urocortin 2 | Yes |
| AdmR | Adr | Yes |
| Adcyap1r1 | PACAP | Yes |
| mGLuR6 | Homo-AMPA | Yes |
| GPR 119 | PF04713082 | Yes |
| GPR83/npy3-36 § | NPY 3-36 | Yes |
| Gpr17/P2y6 | UDP | NS |
| CCR4 | CCL22 | Yes |
| CCR5 | RANTES | Yes |
| Gpr40 | GW9508 | Yes |
| SSTR2 | Sst14 | Yes |
| CB1 | CP-55940 | Yes |
| 5HT4 | Cisapride | Yes |
| Gpr17 | LTD4 | Yes |
| NPY2R | PYY3-36 | NS |
§
siRNA mediated knock-down in the POA shows that GPR83 is involved in control of BAT activity