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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Exp Eye Res. 2010 Aug 27;91(6):788–792. doi: 10.1016/j.exer.2010.08.013

Fig. 1.

Fig. 1

Oxidation and Reduction Reactions of the Visual Cycle. The classical visual cycle involves reduction and oxidation reactions carried out in the photoreceptors and retinal pigment epithelium (RPE), respectively. RDH enzymes are responsible for both reactions. In the photoreceptor OS, RDHs carry out the NADPH-dependent reduction of all-trans retinal (atRAL) to all-trans retinol (atROL). In the RPE, RDHs are responsible for the NAD+-dependent oxidation of 11-cis retinol (11cROL) to 11-cis retinal (11cRAL).