. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: Exp Eye Res. 2010 Aug 27;91(6):788–792. doi: 10.1016/j.exer.2010.08.013

Table 1.

RDHs Associated with the Visual Cycle^a

RDH	Location	Proposed Visual Cycle Substrate	Proposed Visual Cycle Cofactor	Additional Substrates	Stereospecificity		Disease
RDH	Location	Proposed Visual Cycle Substrate	Proposed Visual Cycle Cofactor	Additional Substrates	Cofactor	Retinoid	Disease
RDH8	ROS, COS	all-trans retinal	NADPH	—	Pro-S	Pro-R	—
RDH12	RIS, CIS	all-trans retinal	NADPH	aldehydes	Pro-S	Pro-R	LCA
retSDR1	COS	all-trans retinal	NADPH	—	Pro-S	Pro-R	—
RDH5	RPE	11-cis retinol	NAD⁺	—	Pro-S	Pro-S	FA
RDH11	RPE, IS	11-cis retinol	NADP⁺	aldehydes	Pro-S	Pro-R	—

References are also noted in text but are as follows for each RDH: RDH8 (Palczewski et al., 1994; Jang et al., 2000; Rattner et al., 2000), RDH12 (Haeseleer et al., 2002; Janecke et al., 2004; Belyaeva et al., 2005), retSDR1 (Haeseleer et al., 1998), RDH5 (Simon et al., 1995; Romert et al., 1998; Yamamoto et al., 1999; Jang et al., 2001), RDH11 (Haeseleer et al., 2002; Kedishvili et al., 2002; Kasus-Jacobi et al., 2003). Abreviations: ROS (rod outer segment), COS (cone outer segment), RIS (rod inner segment), CIS (cone inner segment), RPE (retinal pigment epithelium), IS (inner segment, undefined), LCA (Leber’s Congenital Amaurosis), FA (fundus albipunctatus).