FIG. 3.

OXKO mice fail to maintain intermediate and long wake bouts even during the light period. A: WT and OXKO mice have similar survival of short wake bouts (<60 s). B: intermediate wake bouts (60 –1,000 s) terminate early in OXKO mice due to an absence of the plateau region (log-rank and Wilcoxon tests, P < 0.05). C: although the difference in the right-hand tail region is less striking in the light period, long wake bouts (>1,000 s) terminate earlier in OXKO mice, maintaining the significant difference between genotypes (log-rank and Wilcoxon tests, P < 0.05). This analysis was performed on light-period wake bouts to avoid possible biasing effects of the very long wake bouts in WT mice during the dark period. These plots show the survival of subsets of all wake bouts; the power-law behavior in survival of wake-bout durations is apparent only when all wake bouts are considered in the analysis due to the relationship between the survival curve and the underlying distribution.