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Model simulations replicate the differences in sleep/wake behavior between WT and OXKO mice. A and B: WT and OXKO mice have similar daily percentages of wakefulness, NREM sleep, and REM sleep. C and D: compared with WT mice, OXKO mice have more wake and NREM sleep bouts. E and F: the mean durations of wake and NREM bouts are shorter in OXKO mice. All of these differences are reflected in the simulated behavior.
