FIG. 7.

In OXKO mice, time spent in wakefulness occurs in short- and intermediate-length bouts rather than long bouts. This shift as shown by histograms with bins corresponding to short (<60 s), intermediate (60 –1,000 s), long (1,000 – 6,000 s), and very long (>6,000 s) wake bouts. A: WT mice spend much of their waking time in long and very long wake bouts. B: OXKO mice show reduced numbers of long and very long wake bouts balanced by increased numbers of short- and intermediate-length bouts. The absence of bouts >6,000 s in OXKO mouse data highlights the inability of these animals to maintain very long bouts.