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Statistical parametric map of significantly greater 2-year declines in regional CMRgl in cognitively normal APOE ɛ4 heterozygotes than in ɛ4 noncarriers (P < 0.001, uncorrected for multiple comparisons). Significant CMRgl declines (in color) are superimposed onto the left lateral, right lateral, left medial, and right medial surfaces of a spatially standardized volume-rendered MRI.
