Figure 1. Norepinephrine release from isolated rat hearts is modulated by adenosine agonists.
A) Mean of absolute NE concentration released during electrical field stimulation without pharmacologic modulation (Wistar n = 18, SHR n = 14; p<0.01). B) The effect of capadenoson and CCPA (capadenoson 6 · 10−8 M n = 6, capadenoson 6 · 10−7 M n = 4, CCPA 10−6 M n = 4) in Wistar rats. C) The effect of capadenoson and CCPA (capadenoson 6 · 10−8 M n = 6, capadenoson 6 · 10−7 M n = 5, CCPA n = 7) in SHR. The first stimulation (S1) served as an individual control without intervention; the second stimulation (S2) was performed after 30 minutes pretreatment with either capadenoson or CCPA. S2/S1 expressed as means +/− SEM, * p<0.01 for NE release with pharmacological modulation vs NE release without.