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. 2011 Mar 28;6(3):e18200. doi: 10.1371/journal.pone.0018200

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Marchi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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BBB integrity was assessed by Evans blue (A) and serum S100β (B) measurements. Evans blue is an indicator of paracellular leakage while S100β is a surrogate serum marker of the integrity of the cerebrovascular endothelial interface. Both methods revealed a reduction of pilocarpine-induced BBB damage in dexamethasone-pretreated animals (DEXA-PILO). Similar efficacy was previously reported for IL1-RA (see [29]). The asterisks refers to p<0.05 by paired t-test, n = 5 rats per group.