Figure 5. Efficacy of dexamethasone and ACTH in drug resistant pediatric epilepsy.

Data relative to the efficacy of methyl-prednisolone and hydrocortisone are presented in Figure S3. (A) A total of 53 treatments were evaluated. Treatments were administered as described in the Methods and Table S1. Seizures were assessed by behavioral and EEG observations. The values reported refer to decrease in seizure burden compared to baseline EEG seizure quantification. T-test was used to assess significance. (B) Mosaic plot showing the correlation between etiology of epilepsy and likelihood of a response ≥50%. Note that etiology did not always predict response. Noteworthy, dysplasia and other non-encephalopathic diseases responded to the treatments. Cryptogenic seizures were least affected. Bar width is proportional to the number of observations. Colors refer to the response as indicated in the inset.