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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Pharmacol Biochem Behav. 2011 Feb 4;98(3):349–355. doi: 10.1016/j.pbb.2011.02.001

Figure 5.

Figure 5

Effect of NCGC00168459 on pleasure-seeking behavior in the FUST. Naïve 129S1/SVImJ male mice received an icv infusion of vehicle or NCGC00168459 for seven days and then underwent the FUST. Odor (water vs. urine), treatment (vehicle vs. NCGC00168459), and interaction significantly affected length of time spent sniffing (two-way repeated measures ANOVA, F-odor(1,28)=392.3, p<0.0001; F-treatment(1,28)=36.36, p<0.0001; F-interaction( 1,28)=54.15, p<0.0001). Treatment had no significant effect on time spent sniffing water (a) (Bonferroni post-test, t=0.2758, p>0.05). Infusion with NCGC00168459 significantly increased time spent sniffing urine (b) (Bonferroni post-test, t=8.282, p<0.001). PDE4 inhibitor NCGC00167114 infusion also significantly increased sniffing preference (c) (t(28)=2.352, p=0.058). Data are mean ± SD. *: p<0.05.