Table 3.

Patient characteristics that were significantly different between the SH2 and DNA binding domain groups by age subgropus. Unless otherwise noted, number (percent) are presented (N= 19).

Phenotype	Severity	DNA Mutation N=10	SH2 Mutation N=9	P value*
Subjects less than 18 years of age
Subjects under 18 years of age
Scoliosis (degrees)	<10	9 (90.0%)	5 (55.6%)	0.036
	10–14	1 (10.0%)	0 (0.0%)
	15–20	0 (0.0%)	4 (44.4%)
	>20	0 (0.0%)	0 (0.0%)
Highest IgE	Median, (IQR+)	18850 (13900,22500)	5030 (2240, 10100)	0.013
Subjects 18 years of age or older
Sinusitis Otitis (number of episodes in worst year)	1–2	5 (20.0)	1 (4.8)	0.021
	3	2 (8.0)	0 (0.0)
	4–6	6 (24.0)	3 (14.3)
	>6	12 (48.0)	17 (81.0)
High Palate	Present	16 (66.7)	19 (85.0)	0.027
	Absent	8 (33.3)	1 (5.0)
Increase in Interalar distance	<1 SD	6 (24.0)	0 (0.0)	0.035
	1–2 SD	3 (12.0)	3 (15.0)
	>2SD	16 (64.0)	17 (85.0)

^*P-values determined by Fisher’s exact test for binary variables, Cochran-Armitage trend test for ordinal variables, and Wilcoxon Rank test for highest IGE.

⁺IQR = Interquartile Range

Percentages provided are based on the number of non-missing values.