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. Author manuscript; available in PMC: 2012 Apr 18.
Published in final edited form as: Brain Res. 2011 Mar 5;1385:246–256. doi: 10.1016/j.brainres.2011.02.013

Figure 3.

Figure 3

Representative images of H&E stained rat brain sections at the hippocampal area 2 d after cerebral HI. The rat pups were subjected to a hypothermic exposure for 4 h, followed by an immediate IGF treatment (HT4h+IGF0h). No pathological changes were found in the sham group (A). Cerebral HI caused severe tissue damage in the ipsilateral cortex, striatum, hippocampus and white matter areas of the normothermia and vehicle-treated group (B). IGF-1 treatment (C) or hypothermic treatment (D) alone did not attenuate brain injury, while the combination of hypothermia and IGF-1 treatment (E) reduced the HI-induced brain damage. Scale bar: 500 μm.