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. Author manuscript; available in PMC: 2012 Apr 18.
Published in final edited form as: Brain Res. 2011 Mar 5;1385:246–256. doi: 10.1016/j.brainres.2011.02.013

Figure 5.

Figure 5

NF-κB levels in the ipsilateral rat brain following cerebral HI. Each experimental group had 5 animals. After HI, rats were exposed to a hypothermia (HT) or a normothermia (NT) condition for 4 h and then immediately treated with either IGF-1 or vehicle. Cerebral HI caused activation of NF-κB at 2 h after HI and the activation lasted for 24 h. Hypothermic treatment decreased the NF-κB level at 2–4 h following cerebral HI as compared to the normothermic groups. However at 12 h following HI, the NF-κB level in the HT+BSA group was increased, while the level in the HT+IGF-1 group still remained at a lower level as compared to other 3 HI groups (P<0.05). NF-κB level at 24 h was still higher in all HI groups as compared to the sham group. But no significant difference was detected among the four HI groups. Results are expressed as the Mean±SD of 5 animals for each group. *P<0.05 vs to the sham group at the same time point. # P<0.05 vs the NT+BSA group at the same time point.