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. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: J Chromatogr A. 2010 Nov 16;1218(15):2091–2097. doi: 10.1016/j.chroma.2010.10.107

Figure 1.

Figure 1

Cation-Exchange HPLC of XOMA 3AB Antibodies. The three XOMA 3AB reference antibodies (Ab-A, Ab-B, and Ab-C) display multiple acidic and basic isoforms typical of recombinant monoclonal antibody drug products. The force-oxidized samples of each of these antibodies exhibit broad peak profiles indicating underlying structural heterogeneity. Anion-exchange HPLC (Figure 2) was evaluated as an orthogonal charge-based technique to better characterize the potential modifications.