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. 2010 Oct 22;5:91–105. doi: 10.2147/CE.S8008

Figure 1.

Figure 1

Statins share a number of chemical similarities. They all contain a dihydroxy heptanoic acid HMG-CoA like moiety, which competes for binding to HMG-CoA reductase. The fungal statins all have a naphthalenyl ester base structure. The synthetic statins share a fluorinated phenyl group with a methylethyl side chain and a base structure with five or six-member ring with one or more carbon atoms replaced by nitrogen. All these structural elements participate in binding to HMG-CoA reductase.Copyright © 2009. Adapted with permission from McKenney JM, Ganz P, Wiggins BS, et al. In: Ballantyne CM, editor. Clinical Lipidology A Companion to Braunwald’s Heart Disease. Philadelphia, PA: Saunders Elsevier; 2009.