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Characteristics and classifications of different histone deacetylase enzymes
| HDAC family | Class | HDAC enzyme | Location | Substrate | Targeted by HDACi? |
|---|---|---|---|---|---|
| Zinc-dependent | I | 1,2,3,8 | Nucleus | Histone | Yes |
| IIa/b | 4,5,6,7,9,10 | Nucleus, cytoplasm | Histone and nonhistone | Yes | |
| IV | 11 | Nucleus | Unknown | Yes | |
| Zinc-independent | III | SIRT 1,2,3,4,5,6,7 |
Mitochondrial, unknown | Nonhistone | No |
Abbreviations: HDAC, histone deacetylase; HDACi, histone deacetylase inhibitors.
