Figure 1.

Percentage of tumor burden following different doses of treatment with rapamycin alone. Tumor burden is significantly different between rapamycin doses (P < 0.002). Eyes treated with rapamycin at 0.167, 3.33, and 6.67 mg/kg showed a significant decrease in tumor burden in comparison with the vehicle control group (P = 0.019, P = 0.001, P = 0.009, respectively) and the 0.00333 mg/kg dose response (P = 0.023, P = 0.001, P = 0.010, respectively).

Note: *Denotes statistical significant percentage reduction from the vehicle control (80% DMSO).

Abbreviation: DMSO, dimethyl sulfoxide.