Figure 3.

Reduction in the percentage of tumor hypoxia following different doses of treatment with rapamycin. The percentage of hypoxia is significantly different between the rapamycin doses (P < 0.002). Eyes treated with rapamycin at 3.33 mg/kg showed a significant decrease in the percentage of hypoxia in comparison with the groups treated with 0.00333 and 0.167 mg/kg of rapamycin (P = 0.024 and P = 0.052, respectively).

Note: *Denotes statistical significant percentage difference in comparison with the groups treated with 0.00333 and 0.167 mg/kg.

Abbreviation: DMSO, dimethyl sulfoxide.