Table 1.
Baseline demographics and clinical characteristics
| Adaptive pacing therapy (n=159) | Cognitive behaviour therapy (n=161) | Graded exercise therapy (n=160) | Specialist medical care alone (n=160) | Overall (n=640) | ||
|---|---|---|---|---|---|---|
| Demographic data | ||||||
| Age (years) | 39 (11) | 39 (12) | 39 (12) | 37 (11) | 38 (12) | |
| Female | 121 (76%) | 129 (80%) | 123 (77%) | 122 (76%) | 495 (77%) | |
| White | 146 (92%) | 151 (94%) | 148 (93%) | 150 (94%) | 595 (93%) | |
| Any ME group membership | 31 (19%) | 26 (16%) | 25 (16%) | 23 (14%) | 105 (16%) | |
| Clinical data | ||||||
| International CFS criteria12 | ||||||
| As randomised | 99 (62%) | 100 (62%) | 98 (61%) | 100 (63%) | 397 (62%) | |
| Actual | 107 (67%) | 106 (66%) | 106 (66%) | 108 (68%) | 427 (67%) | |
| London ME criteria13 | ||||||
| As randomised | 89 (56%) | 90 (56%) | 89 (56%) | 89 (56%) | 357 (56%) | |
| Actual | 81 (51%) | 84 (52%) | 84 (53%) | 80 (50%) | 329 (51%) | |
| Any depressive disorder | ||||||
| As randomised | 55 (35%) | 55 (34%) | 54 (34%) | 55 (34%) | 219 (34%) | |
| Actual | 54 (34%) | 52 (32%) | 54 (34%) | 53 (33%) | 213 (33%) | |
| Any psychiatric disorder* | 75 (47%) | 75 (47%) | 73 (46%) | 77 (48%) | 300 (47%) | |
| Duration of illness (months) | 33 (16–69) | 36 (16–104) | 35 (18–67) | 25 (15–57) | 32 (16–68) | |
| Body-mass index (kg/m2) | 25·9 (5·5) | 25·4 (5·2) | 25·5 (4·6) | 25·1 (4·5) | 25·5 (5·0) | |
Data are mean (SD), n (%), or median (IQR). ME=myalgic encephalomyelitis. CFS=chronic fatigue syndrome.
*
Psychiatric disorders included any depressive disorder and any anxiety disorder, including phobias, obsessive-compulsive disorder, and post-traumatic stress disorder.