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. 2011 Mar 9;31(10):3602–3609. doi: 10.1523/JNEUROSCI.6388-10.2011

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Copyright © 2011 the authors 0270-6474/11/313602-08$15.00/0

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Figure 7. — Coincident CB1R activation and postsynaptic depolarization trigger long-lasting suppression of evoked responses. A, Pooled data show the effect of bath application of the CB1R agonist WIN coupled to somatic depolarization. Following a WIN-induced 15% depression of EPSCs' amplitude, EX neurons were transiently depolarized (as in A). After 11 min of WIN application, AM-251 was applied for the remainder of the experiment (black circles). LTD triggered by coincident CB1R activation and postsynaptic depolarization was prevented by bath application of D-APV (white circles). B, PPR values for neurons in A. White circles represent each data point and bar graphs show their average and SEM. **p < 0.01. Ctrl., Control; Depol., depolarization.