Skip to main content
. 2011 Apr;21(4):525–534. doi: 10.1101/gr.114116.110

Figure 4.

Figure 4.

HCC1187 t(11;16) duplication at a breakpoint. (A) Schematic representation of the products of the reciprocal translocation between chromosomes 11 and 16 in HCC1187 (Chr S and Chr R). The duplicated region of Chr 16 is shown between blue dashed lines. The approximate location of fosmids used in FISH mapping is shown. A 1.3-kb duplicated piece of chromosome 11 is shown with a red bar. (B) Hybridization of Chr S and Chr R to a custom NimbleGen oligonucleotide array covering a specified region on chromosome 16. Breakpoints are indicated with a broken line. (C) Breakpoint mapping by FISH using fosmids G248P87664H6 (shown in red) and G248P86304B9 (shown in green). Chromosome 16 is shown in blue. Normal chromosome 16 is indicated with a red arrow, the der (16) with a white arrow (Chr S), and the der(11) with an open white arrow (Chr R) (confirming single-color FISH shown in Howarth et al. 2008).