Figure 4.

Diagram representing the insertion site in the der(X) resulting from insertion of chromosome 19 material into Xq28 in proband 6. (Gray shaded area within the inset box) The 3-nucleotide span of microhomology shared at the distal insertion breakpoint. (Small black arrows) The positions of primers used to generate the PCR fragment and obtain the junction sequence. Genes are displayed as blue and gray bars below, and show the disruption of MECP2 as well as the two possible fusion gene products that could result from the insertion.