Levels of interleukin-1b (IL1b), IL5, and IL8 were increased in high risk cysts (high grade dysplasia (HGD) or invasive cancer (Ca), n=19) compared to low risk cysts (low grade dysplasia (low) or moderate dysplasia (mod), n=21), *p<0.05. In a multivariate predictive analysis model, only IL1b remained a significant predictor of dysplasia (p=0.0003).