Skip to main content
. 2011 Mar 10;2(2):122–128. doi: 10.3945/an.110.000265

Figure 1.

Figure 1

Biosynthesis of Sec and de novo synthesis of Cys. The complete synthesis of Sec on its tRNA in eukaryotes and archaea wherein selenite and ATP are substrates for SPS2 yielding selenophosphate that interacts with SecS, and the intermediate, likely dehydroalanine, to generate Sec-tRNA[Ser]Sec is shown on the right in the upper pathway. In the lower pathway, the de novo synthesis of Cys is shown in mammals wherein sulfide and ATP are substrates for SPS2 yielding thiophosphate that interacts with SecS, and the intermediate, likely dehydroalanine, to yield Cys-tRNA[Ser]Sec. See text for further details.