Table 1.

Polygenic score analyses within the bipolar samples, the phenotype of interest is Research Diagnostic Criteria (RDC) schizoaffective bipolar disorder^a

Sample	P
Wellcome Trust Case-Control Consortium bipolar disorder sample
RDC schizoaffective bipolar disorder subset (n = 277) v. non-schizoaffective bipolar disorder subset (n = 1552)	0.00059
All RDC schizoaffective bipolar disorder: DSM–IV schizoaffective bipolar disorder subsets (n = 97) v. DSM–IV bipolar I disorder subset (n = 180)	0.42
Replication University College London bipolar disorder sample
Schizoaffective bipolar disorder subset (n = 74) v. non-schizoaffective bipolar disorder subset (n = 409)	0.0070

a. Comparison analyses were performed using logistic regression. All P-values are one-sided.