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. Author manuscript; available in PMC: 2011 Mar 29.
Published in final edited form as: Kidney Int. 2010 May 26;78(4):363–373. doi: 10.1038/ki.2010.137

Figure 7. Targeting ILK in vivo ameliorates albuminuria after ADR injury.

Figure 7

(a) Upregulation of ILK in the glomeruli in vivo after podocyte injury induced by ADR. Glomeruli were isolated from mice injected with ADR for 7 days. Whole-glomerular lysates were immunoblotted with antibodies against ILK and α-tubulin. Numbers (1 and 2) indicate each individual animal in a given group. (b) Inhibition of ILK activity by QLT0267 reduced albuminuria in ADR nephropathy. Mice injected with ADR were administrated with different doses of QLT0267 for 7 days. Urinary albumin level was determined and corrected to urine creatinine. Urine albumin was expressed as mg per mg creatinine and presented as mean ± s.e.m. *P < 0.05 versus ADR alone (n = 6). ADR, adriamycin; ILK, integrin-linked kinase.