Table 1.
Effect of pravastatin concentration and incubation time on the amount of pravastatin loaded on human carrier erythrocytes at 25oC by endocytosis
| Drug concentration(µg/ml) | Drug incubation times | |||
|---|---|---|---|---|
| 15 min. | 30 min. | 60 min. | 120 min. | |
| 2× 103 | 292 ± 15.5 | 395 ± 40.1* | 532 ± 39.1* | 544 ± 23.0 |
| 4× 103 | 415 ± 20.0# | 971 ± 3 7.1*# | 1366 ± 63.5*# | 1286 ± 36.5# |
| 8× 103 | 627 ± 26.8# | 2006 ± 36.6*# | 2561 ± 111*# | 2499 ± 46.0# |
| 10× 103 | 706 ± 28.5# | 2352 ± 42.0*# | 3211 ± 66.5*# | 3170 ± 134# |
Data were tested by one-way analysis of variance and represented as mean ± SD. Six samples in each group (N = 6). Bonferroni multiple comparison tests using SPSS software was performed to determine differences between mean values. * Significantly different according to time at p < 0.01, # significantly different according to concentration at p < 0.01.