Table 2.
Effect of pravastatin concentration and incubation time on the amount of pravastatin loaded on human carrier erythrocytes at 37oC by endocytosis
| Drug concentration(µg/ml) | Drug incubation times | |||
|---|---|---|---|---|
| 15 min. | 30 min. | 60 min. | 120 min. | |
| 2× 103 | 223 ± 23.5 | 1047 ± 127* | 1317 ± 70.0 | 1663 ± 245 |
| 4× 103 | 489 ± 19.0# | 1795 ± 13.7*# | 3031 ± 297*# | 3788 ± 339*# |
| 8× 103 | 907 ± 14.5# | 2074 ± 267* | 4169 ± 222*# | 5540 ± 479*# |
| 10× 103 | 1047 ± 33.5# | 2725 ± 241*# | 4690 ± 178*# | 6900 ± 88.0*# |
Data were tested by one-way analysis of variance and represented as mean ± SD. Six samples in each group (N = 6). Bonferroni multiple comparison tests using SPSS software was performed to determine differences between mean values. * Significantly different according to time at p < 0.01, # significantly different according to concentration at p < 0.01