Table 4.

Erythrocyte osmotic fragility of unloaded erythrocytes and erythrocytes loaded with 8, 4 and 2 mg/ml pravastatin. Values are percent hemolysis in corresponding salt concentrations

NaCl %	Control	2 mg	4 mg	8 mg
0.80	1.30 ± 0.66	0.54 ± 0.01	0.92 ± 0.01	1.19 ± 0.01
0.70	5.35 ± 1.34	0.74 ± 0.01	1.23 ± 0.01	2.80 ± 0.02
0.60	12.3 ± 1.97	7.26 ± 0.07	9.53 ± 0.06	8.99 ± 0.07
0.50	29.7 ± 3.42	15.0 ± 0.03	17.2 ± 0.04	15.2 ± 0.04
0.45	56.5 ± 3.50	55.6 ± 0.08	71.2 ± 0.09	73.2 ± 0.10
0.40	74.1 ± 3.04	73.5 ± 0.12	88.7 ± 0.14	94.0 ± 0.17
0.35	80.45 ±1.56	76.8 ± 0.11	93.9 ± 0.09	94.1 ± 0.16
0.30	84.4 ± 4.14	77.4 ± 0.11	95.8 ± 0.12	97.7 ± 0.12
0.20	89.6 ± 4.60	78.6 ± 0.12	97.7 ± 0.10	99.0 ± 0.02
0.10	96.8 ± 4.80	80.8 ± 0.5	100 ± 0.11	100 ± 0.03
0.00	100 ±0.05	100 ± 0.01	100 ± 0.11	100 ± 0.03

Data were tested by one-way analysis of variance and represented as mean ± SD. Three samples in each group (N = 3). Bonferroni multiple comparison tests using SPSS software was performed to determine differences between mean values at (P ≤ 0.01).