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Increasing Tx biosynthesis during atherogenesis in LDLR-KO mice. Excretion of the major urinary metabolite of Tx, 2,3-dinor TxB2, in LDLR-KO mice on a Western-type diet receiving placebo (open bars), indomethacin (hatched bars), or nimesulide (closed bars) at 8 weeks of age and after 18 weeks of treatment (26 weeks of age). (*, P < 0.001.)
