Table 2.

Selected pharmacokinetic parameters of domperidone after a single administration of Motilium tablet or domperidone hydrogel to beagle dogs at a dose of 10 mg/body (n = 3).

Parameter	Units	Motilium tablet	Domperidone hydrogel
Tmax	h	0.44 ± 0.10	1.17 ± 0.29**
Cmax	ng/mL	56.95 ± 6.63	70.05 ± 12.27
AUC0-24	H · ng/mL	382.11 ± 52.71	829.64 ± 105.09**
Vz	l/kg	35.16 ± 2.06	17.49 ± 2.17*
Cl	l/h/kg	2.04 ± 0.26	0.93 ± 0.08**
MRT	h	10.04 ± 1.05	10.85 ± 0.49

*P < .05 or **P < .01 versus tablet group.