Table 2.
Association between the four measures of adherence and virological failure in the overall population.
| N | Virological failure: N (%) | OR [95% CI] | P | |
|---|---|---|---|---|
| Self-report questionnaire (all three items)* | ||||
|
| ||||
| 100% adherent | 223 | 63 (28.2) | 1 | |
| At least one missed HAART dose | 34 | 11 (32.3) | 1.21 [0.56–2.64] | .62 |
|
| ||||
| Visual analog scale* | ||||
|
| ||||
| 10 | 184 | 54 (29.3) | 1 | |
| 9 | 62 | 18 (29.1) | 0.98 [0.52–1.85] | .70 |
| <9 | 11 | 2 (18.2) | 0.54 [0.11–2.55] | |
|
| ||||
| Antiretroviral drug concentrations (ng/mL) | ||||
|
| ||||
| ≥1000 for EFV or ≥3000 for NVP | 241 | 61 (25.3) | 1 | |
| <1000 for EFV or <3000 for NVP | 18 | 13 (72.2) | 7.67 [2.63 –22.40] | <.0001 |
|
| ||||
| Macrocytosis (MCV ≥100 fL)** | ||||
|
| ||||
| Yes | 229 | 62 (27.1) | 1 | |
| No | 23 | 12 (52.1) | 2.94 [1.23–7] | .015 |
|
| ||||
| Self-report questionnaire plus macrocytosis | ||||
|
| ||||
| 100% adherent | 200 | 56 (28) | 1 | |
| At least one mistake | 50 | 18 (36) | 1.44 [0.75–2.78] | .27 |
|
| ||||
| Self-report questionnaire plus drug assays | ||||
|
| ||||
| 100% adherent | 209 | 54 (25.8) | 1 | |
| At least one mistake | 48 | 20 (41.7) | 2.05 [1.07–3.93] | .031 |
OR: odds ratio; CI: confidence interval, *Available for 257 patients, **Available for 252 patients.