Table 3.
Association between the four measures of adherence and virological failure in the previously HAART-naïve population.
| N | Virological failure: N (%) | OR [95% CI] | P | |
|---|---|---|---|---|
| Self-report questionnaire (all three items)* | ||||
|
| ||||
| 100% adherent | 134 | 22 (16.4) | 1 | |
| At least one missed HAART dose | 22 | 8 (36.4) | 2.91 [1.09–7.76] | .034 |
|
| ||||
| Visual analog scale* | ||||
|
| ||||
| 10 | 110 | 20 (18.1) | 1 | |
| 9 | 39 | 8 (20.5) | 1.16 [0.46–2.90] | .78 |
| <9 | 7 | 2 (28.6) | 1.8 [0.32–9.95] | |
|
| ||||
| Antiretroviral drug concentrations (ng/mL) | ||||
|
| ||||
| ≥1000 for EFV or ≥3000 for NVP | 149 | 24 (16.1) | 1 | |
| <1000 for EFV or <3000 for NVP | 9 | 6 (66.7) | 10.42 [2.43–44.54] | .002 |
|
| ||||
| Macrocytosis (MCV ≥ 100 fL)** | ||||
|
| ||||
| Yes | 141 | 23 (16.3) | 1 | |
| No | 14 | 7 (50) | 5.13 [1.64–16.02] | .007 |
|
| ||||
| Self-report questionnaire and macrocytosis | ||||
|
| ||||
| 100% adherent | 121 | 18 (14.9) | 1 | |
| At least one mistake | 32 | 12 (37.5) | 3.43 [1.43–8.22] | .006 |
|
| ||||
| Self-report questionnaire and drug assays | ||||
|
| ||||
| 100% adherent | 129 | 20 (15.5) | 1 | |
| At least one mistake | 27 | 10 (37) | 3.20 [1.28–8] | .015 |
OR: odds ratio; CI: confidence interval, *Available for 156 patients, **Available for 155 patients.