Table 1.

Proportion of single and double carriers of Jewish founder mutations, risk of cancer and age at cancer diagnosis in the Israeli Familial Cancer Service series and Breast Cancer Cohort

	Number tested in carrier families	Number of all carriers (%)	Number of female carriers (%)	Affected females	Mean age of diagnosis of breast cancer
Clinical series	1779	1191	942
Single mutation		1169	926		48.1 (±13.0)
BRCA1 185delAG		556 (46.68)	444 (47.13)	178 Breast (40.1%)	46.8 (±12.3)
				88 Ovary (19.8%)
BRCA1 5382insC		181 (15.20)	151 (16.03)	72 Breast (47.7%)	46.8 (±14.0)
				20 Ovary (13.2%)
BRCA2 6174delT		432 (36.27)	331 (35.14)	122 Breast (36.9%)	50.8 (±13.0)
				22 Ovary (6.6%)
Double mutation		22 (1.85)	16 (1.70)	8 Breast	44.6 (±13.5)
				1 Ovary
BRCA1 185delAG + BRCA2 6174delT		18 (1.51)	14 (1.49)	6 Breast (42.9%)	47.0 (±13.5)
				1 Ovary (7.1%)
BRCA1 5382insC + BRCA2 6174delT		4 (0.34)	2 (0.21)	2 Breast	37.5 (±13.5)
BRCA1 185delAG + BRCA1 5382insC		0	0
Breast cancer cohort study	1794 All	135	135	135
	1102 AJa
Non-carriers		1659	1659	1659	62.1 (±13.5)
Single mutation
BRCA1 185delAG		61	61	61	56.0 (±15.5)
BRCA1 5382insC		17	17	17	51.5 (±13.6)
BRCA2 6174delT		53	53	53	57.3 (±12.8)
Double mutation
BRCA1 185delAG + BRCA2 6174delT		4 (0.30)	4 (0.30)	4	49.3 (±17.0)

^aAJ, Ashkenazi Jews.