Table 2.
Synthetic nanocarriers tested for cancer gene therapy in human Phase I clinical trials.
| Nanocarrier | Therapeutic gene | Cancer | Route of administration |
|---|---|---|---|
| DC (3 beta-[n-(N′, N′-dimethylaminoethane)-carbamoyl]cholesterol): DOPE (dioleoylphosphatidylethanolamine) | E1A | Breast/ovarian | Intratumoral (it)/intraperitoneal (ip) |
| DC (3 beta-[n-(N′, N′-dimethylaminoethane)-carbamoyl]cholesterol): Chol (cholesterol) | EGFR | Head & neck | Intratumoral |
| DOTAP (N-[1-(2, 3-dioleoyloxy)propyl]-N,N,N-trimethylammonium Chloride): DOPE (dioleoylphosphatidylethanolamine) | p53 | Solid tumor | Intravenous (iv) |
| DOTAP (N-[1-(2, 3-dioleoyloxy)propyl]-N,N,N-trimethylammonium Chloride): Chol (cholesterol) | BiKDD | Pancreatic cancer | Intravenous (iv) |
| DOTAP (N-[1-(2, 3-dioleoyloxy)propyl]-N,N,N-trimethylammonium Chloride): Chol (cholesterol) | E1A | Breast/ovarian | Intravenous (iv) |
| DOTAP (N-[1-(2, 3-dioleoyloxy)propyl]-N,N,N-trimethylammonium Chloride): Chol (cholesterol) | Fus1 | Lung | Intravenous (iv) |
| DOTMA (N-[1-(2,3-dioleyloxy)propyl]-N,N,N-trimethylammonium Chloride): Chol (cholesterol) | IL-2 | Head & neck | Intratumoral (it) |
Source: www.cancertrials.gov.