Table 4.
Relative risk of breast cancer by combinations of receptor status and quintiles of HCA, MDM and meat intake in women in the Nurses Health Study (1996–2006)
|
Quintile HCA Intake (ng/day)/Mutagenic Activity (revertants/day) |
||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | P trend | |
| Estrogen positive/Progesterone positive | ||||||
| Total red meat (1994–2002 FFQ) | ||||||
| Cases | 281 | 174 | 244 | 237 | 238 | |
| Multivariate RR | 1 | 0.89 (0.73–1.08) | 0.91 (0.76–1.08) | 0.92 (0.77–1.10) | 0.91 (0.75–1.10) | 0.46 |
| Total white meat (1994–2002 FFQ) | ||||||
| Cases | 295 | 168 | 256 | 233 | 222 | |
| Multivariate RR | 1 | 1.22 (1.01–1.49) | 1.08 (0.91–1.28) | 0.90 (0.76–1.08) | 0.97 (0.81–1.17) | 0.15 |
| Processed meat (1994–2002 FFQ) | ||||||
| Cases/Person-years | 237 | 239 | 194 | 237 | 267 | |
| Multivariate RR† | 1 | 1.03 (0.86–1.24) | 0.90 (0.74–1.09) | 0.94 (0.78–1.13) | 1.06 (0.87–1.28) | 0.54 |
| Total MeIQx | ||||||
| Cases | 242 | 219 | 226 | 244 | 243 | |
| Multivariate RR† | 1 | 0.88 (0.73–1.06) | 0.89 (0.74–1.08) | 0.97 (0.81–1.17) | 0.93 (0.77–1.12) | 0.88 |
| Total PhIP | ||||||
| Cases | 247 | 223 | 228 | 252 | 224 | |
| Multivariate RR† | 1 | 0.90 (0.75–1.08) | 0.92 (0.76–1.10) | 1.01 (0.84–1.21) | 0.89 (0.74–1.08) | 0.58 |
| Total DiMeIQx | ||||||
| Cases | 242 | 211 | 234 | 238 | 249 | |
| Multivariate RR† | 1 | 0.84 (0.70–1.01) | 0.94 (0.79–1.13) | 0.96 (0.80–1.15) | 0.98 (0.82–1.18) | 0.56 |
| Meat derived mutagenic activity | ||||||
| Cases | 221 | 235 | 244 | 247 | 227 | |
| Multivariate RR† | 1 | 1.05 (0.87–1.26) | 1.09 (0.91–1.31) | 1.10 (0.91–1.33) | 0.99 (0.82–1.20) | 0.77 |
| Estrogen negative/Progesterone negative | ||||||
| Total red meat (1994–2002 FFQ) | ||||||
| Cases | 68 | 46 | 62 | 57 | 62 | |
| Multivariate RR | 1 | 0.99 (0.68–1.45) | 1.00 (0.71–1.43) | 1.02 (0.71–1.47) | 1.05 (0.72–1.53) | 0.79 |
| Total white meat (1994–2002 FFQ) | ||||||
| Cases | 85 | 31 | 59 | 66 | 54 | |
| Multivariate RR | 1 | 0.77 (0.50–1.17) | 0.93 (0.66–1.31) | 0.86 (0.62–1.20) | 0.88 (0.61–1.26) | 0.53 |
| Processed meat (1994–2002 FFQ) | ||||||
| Cases | 65 | 56 | 60 | 52 | 62 | |
| Multivariate RR† | 1 | 0.86 (0.60–1.24) | 0.99 (0.69–1.42) | 0.77 (0.53–1.12) | 0.90 (0.61–1.31) | 0.61 |
| Total MeIQx | ||||||
| Cases | 67 | 63 | 56 | 54 | 55 | |
| Multivariate RR† | 1 | 0.91 (0.64–1.29) | 0.83 (0.58–1.19) | 0.78 (0.54–1.13) | 0.79 (0.54–1.15) | 0.23 |
| Total PhIP | ||||||
| Cases | 69 | 68 | 51 | 61 | 46 | |
| Multivariate RR† | 1 | 1.02 (0.73–1.43) | 0.76 (0.52–1.09) | 0.94 (0.66–1.34) | 0.73 (0.50–1.08) | 0.12 |
| Total DiMeIQx | ||||||
| Cases | 62 | 67 | 63 | 58 | 45 | |
| Multivariate RR† | 1 | 1.06 (0.75–1.51) | 1.01 (0.71–1.45) | 0.92 (0.64–1.33) | 0.74 (0.50–1.10) | 0.06 |
| Meat derived mutagenic activity | ||||||
| Cases | 62 | 61 | 60 | 55 | 57 | |
| Multivariate RR† | 1 | 0.97 (0.68–1.39) | 0.96 (0.67–1.38) | 0.91 (0.63–1.32) | 0.93 (0.64–1.36) | 0.70 |
*
Numbers in parenthesis next to RR are 95% confidence intervals
†
Multivariate models adjusted for same covariates as denoted in table 3