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. 2001 Mar 13;98(6):3369–3374. doi: 10.1073/pnas.051551698

Figure 5.

Figure 5

PXR activation protects against LCA-induced hepatotoxicity. Wild-type (A, C, and E) and PXR−/− (B, D, and E) mice were treated with vehicle alone (A and B), LCA (C and D), or LCA and PCN (E and F). Liver sections were prepared for histology and stained with hematoxylin and eosin. Areas of severe necrosis in panels C, D, and E are indicated with arrows. (G) Serum ALT (open bars) and SDH (closed bars) levels were measured in wild-type and PXR−/− mice treated with either LCA and vehicle (Vehicle) or LCA and PCN (PCN). ALT and SDH values in untreated animals were 28 ± 10 units/l and 150 ± 20 units/ml, respectively. Data represent the mean ± SEM of assays performed with serum from six different animals. Statistical differences compared with the same genotype treated with LCA and vehicle: *, P < 0.005; **, P < 0.001.