FIGURE 6.

SDR increased the proportion of NP_366–74 CD8⁺ T cells of total CD8⁺ T cells but did not alter the surface expression of the NP_366–74TCR. A, Staining intensity of the NP366 tetramer on memory CD8⁺ T cells was not changed by exposure to SDR. The proportion of NP_366–74CD8⁺ T cells detected during resting memory (B) and at the peak of the T cell response at day 5 of influenza reinfection (C) was affected by prior SDR experience. Populations shown were sequentially gated on lymphocytes, then CD3⁺CD8⁺ T cells, and finally on the NP_366–74⁺ population. Percentages in the upper right quadrant represent the proportion of NP_366–74CD8⁺ T cells to the total CD8⁺ T cell population.