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A TLR7 agonist, R837, inhibits bronchoconstriction in guinea pigs in vivo. Bronchoconstriction was induced by means of electrical stimulation of the vagus nerves (circles) or by means of intravenous administration of acetylcholine (squares), and the effect of cumulative increasing doses of R837 administered intravenously was measured (n = 9 for vagal stimulation: maximum, 93.0 ± 21.5 mm H2O; n = 4 for acetylcholine: maximum, 70.5 ± 32.2 mm H2O; P ≤ .001 for effect of dose).
