Skip to main content
. Author manuscript; available in PMC: 2011 Mar 29.
Published in final edited form as: J Allergy Clin Immunol. 2010 Dec 17;127(2):462–469. doi: 10.1016/j.jaci.2010.10.029

FIG 4.

FIG 4

The TLR7 antagonist IRS661 partially reverses R837-mediated relaxation and completely reverses PolyUs- and PolyAs-mediated relaxation but does not reverse β2-adrenergic receptor–mediated relaxation of isolated guinea pig tracheas in vitro. Tracheal segments were preincubated with vehicle (open bars), IRS661 (solid bars), or propranolol (gray bars). Contraction of tracheal segments was induced by methacholine, and the effect of R837, PolyUs/As, or isoproterenol was measured (n = 3; maximum, 1.49 ± 0.10 g; R837 ± IRS661, P ≤ .01; PolyUs/As ± IRS661, P ≤ .001; isoproterenol ± propranolol, P ≤ .001). MCh, Methacholine.