FIGURE 3.

Increased expression of IL-4Rα is determined by the local environment. A, IL-4Rα expression on CD4⁺ cells from mesLNs or pooled nondraining lymph nodes (cervical, axial, brachial, inguinal, and popliteal) was compared 14 d after oral H. polygyrus infection and (B) from draining and contralateral popliteal lymph nodes 7 d after s.c. immunization in the footpad with H. polygyrus larvae.C, CD4⁺ IL-4Rα^hi cells were isolated from mesLNs 14 d after H. polygyrus infection and transferred into either 14 d infected or naive recipients. CD4⁺ cells in the recipient mesLNs were analyzed 24 h later by flow cytometry. Data are representative of three or more independent experiments.