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. Author manuscript; available in PMC: 2011 Mar 29.
Published in final edited form as: J Immunol. 2009 Dec 16;184(2):615–623. doi: 10.4049/jimmunol.0902408

FIGURE 5.

FIGURE 5

Early IL-4Rα upregulation predicts subsequent Th2 differentiation. A,WT 4get or 4get/Kn2 dual-reporter mice, in which GFP and huCD2 indicate IL-4 transcription and translation, respectively, were infected with H. polygyrus, and their mesLN CD4+ cells analyzed by flow cytometry at the indicated time points. B, 4get mice were bred on a BALB/c or C57BL/6 background, infected with H. polygyrus, and their mesLN cells analyzed 4 and 14 d later. In both panels, IL-4Rα expression is shown as the mean fluorescence of staining on CD4+ GFP− cells. Error bars indicate the SD of 3–5 mice per group, and data are representative of two independent experiments.