Table 4.
Odds ratios (99% confidence intervals) of a concentration in the top quartile (for gestational age) of the protein listed on the left among children whose placenta had infarct, increased syncytial knots or decidual/ hemorrhage/fibrin deposition compared to children whose placenta did not have that histologic characteristic. Adjustment has been made for gestational age category.
| Protein | Infarct | Increased syncytial knots |
Decidual hem/ fibrin deposition |
|---|---|---|---|
| Cytokines and their receptors | |||
| IL-1β | 0.8 (0.5, 1.4) | 0.6 (0.4, 1.1) | 0.8 (0.4, 1.4) |
| IL-6 | 0.6 (0.3, 1.05) | 0.5 (0.3, 0.96)** | 0.7 (0.4, 1.3) |
| IL-6R | 0.7 (0.4, 1.2) | 0.6 (0.4, 1.1) | 1.1 (0.7, 2.0) |
| TNF-α | 0.7 (0.4, 1.2) | 0.7 (0.4, 1.2) | 0.9 (0.6, 1.6) |
| TNF-R1 | 0.5 (0.3, 1.00) | 0.7 (0.4, 1.2) | 1.1 (0.6, 1.9) |
| TNF-R2 | 0.7 (0.4, 1.2) | 0.7 (0.4, 1.2) | 1.0 (0.6, 1.8) |
| Chemokines | |||
| IL-8 (CXCL8) | 0.6 (0.3, 1.2) | 0.7 (0.4, 1.3) | 1.0 (0.6, 1.7) |
| MCP-1 (CCL2) | 1.1 (0.6, 1.9) | 0.9 (0.5, 1.5) | 0.7 (0.4, 1.3) |
| MCP-4 (CCL13) | 0.9 (0.5, 1.5) | 0.9 (0.5, 1.5) | 1.1 (0.7, 1.9) |
| MIP-1 β (CCL4) | 0.4 (0.2, 0.9) | 0.7 (0.4, 1.2) | 1.0 (0.6, 1.7) |
| RANTES (CCL5) | 0.4 (0.2, 0.7)** | 0.5 (0.3, 0.9)** | 1.1 (0.6, 1.8) |
| I-TAC (CXCL11) | 0.5 (0.3, 1.01) | 0.7 (0.4, 1.2) | 1.0 (0.6, 1.7) |
| Adhesion molecules | |||
| ICAM-1 (CD54) | 0.5 (0.3, 0.99)** | 0.9 (0.5, 1.5) | 0.8 (0.5, 1.5) |
| ICAM-3 (CD50) | 0.2 (0.1, 0.5)** | 0.3 (0.2, 0.6)** | 0.8 (0.4, 1.4) |
| VCAM-1 (CD106) | 0.5 (0.3, 0.9)** | 0.7 (0.4, 1.2) | 1.2 (0.7, 2.1) |
| E-selectin (CD62E) | 0.5 (0.2, 0.9)** | 0.5 (0.3, 0.96)** | 1.1 (0.6, 1.9) |
| Matrix metalloproteinases (MMPs) | |||
| MMP-1 | 0.3 (0.2, 0.7)** | 0.6 (0.4, 1.1) | 1.0 (0.6, 1.7) |
| MMP-9 | 0.5 (0.3, 0.99)** | 0.4 (0.2, 0.7)** | 0.8 (0.5, 1.5) |
| Other indicators of inflammation | |||
| CRP | 0.7 (0.4, 1.2) | 0.9 (0.5, 1.5) | 0.6 (0.3, 1.1) |
| SAA | 0.6 (0.3, 1.04) | 0.7 (0.4, 1.3) | 0.7 (0.4, 1.3) |
| MPO | 0.5 (0.3, 0.95)** | 0.4 (0.2, 0.8)** | 0.8 (0.4, 1.4) |
| Growth factors, their receptors, and binding proteins | |||
| VEGF | 0.6 (0.3, 1.1) | 0.5 (0.3, 0.9)** | 1.3 (0.8, 2.2) |
| VEGF-R1 (Flt-1) | 1.3 (0.7, 2.1) | 2.3 (1.4, 3.8)* | 0.9 (0.5, 1.6) |
| VEGF-R2 (KDR) | 0.5 (0.3, 0.97)** | 0.8 (0.5, 1.3) | 0.9 (0.5, 1.6) |
| IGFBP-1 | 2.0 (1.2, 3.3)* | 2.2 (1.3, 3.5)* | 1.2 (0.7, 2.1) |
| N | 135 | 159 | 137 |
*
Significantly increased risk, p<0.01
**
Significantly reduced risk, p<0.01