Table 3.
Substrate scope for enantioselective bromination. Data determined as in Table 1. Results represent the average of 2–3 runs per substrate.
Entry | Racemic Starting Material | Product | Yield (%) | E.r. |
---|---|---|---|---|
1 | ![]() |
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80 | 97.0:3.0 |
2 | ![]() |
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85 | 97.0:3.0 |
3 | ![]() |
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75 | 96.5:3.5 |
4 | ![]() |
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70 | 96.0:4.0 |
5 | ![]() |
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80 | 94.0:6.0 |
6 | ![]() |
![]() |
70 | 97.0:3.0 |
7 | ![]() |
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65 | 96.5:3.5 |
8 | ![]() |
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85 | 87.0:13.0 |
9 | ![]() |
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77* | 85.0:15.0 |
10 | ![]() |
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70 | 95.0:5.0 |
4 equiv of NBP.