Figure 2.

LCA-mediated liver damage in wild-type, PXR-null, and transgenic mice. Wild-type (A, C, and E), PXR-null (B, D, and F), or Alb-VPSXR transgenic mice (G and H) were given daily treatments of LCA (A, B, E, F, and H) or vehicle (C, D, and G) via gavage for 4 days (24). Wild-type (I) or PXR-null (J) mice were treated with a single i.p. injection of PCN (40 mg/kg) before 4 days of treatment with both LCA (8 mg/day) and PCN (13 mg/kg). (A and B) Photographs of representative livers. (C–J) Liver paraffin sections stained with hematoxylin and eosin. Regions of liver necrosis are marked by arrows in E and F. (×200.)