Table 1.
Loss of PCN-mediated protection from LCA-induced hepatotoxicity in PXR-null mice
| −PCN
|
+PCN
|
||||
|---|---|---|---|---|---|
| WT | PXR-null | VPSXR | WT | PXR-null | |
| LCA-induced histologic liver damage | 7/12 (58.3%) | 7/7 (100%) | 0/5 (0%) | 2/9 (22.2%) | 5/5 (100%) |
WT, wild type.
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