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Hydroxylation of LCA by recombinant CYP3A4 and liver microsomes
| Lithocholic acid metabolites | LCA hydroxylation, pmol/mg⋅min
|
|||||
|---|---|---|---|---|---|---|
| CYP3A4 | CYP3A5 | hLM2 | hLM7 | hLM9 | hLM13 | |
| 6α | 8.0 | 0.04 | 9.9 | 38.2 | 9.1 | 6.3 |
| 6β | 2.1 | 0.0 | 7.3 | 8.8 | 3.4 | 4.4 |
| 7α | 0.1 | 0.0 | 2.8 | 5.0 | 0.8 | 3.0 |
